The CoIN study (Covid-19 impact on wellbeing in families of children with rare neurogenetic syndromes) was established to identify the challenges of the pandemic for families of children with rare neurogenetic syndromes and assess how the risk and resilience processes associate with family well-being. In this longitudinal analysis, we will examine the changes of child and parent mental health during one year, and explore the effect of child, parent and family factors that are associated with such changes.