First meta-analysis to scrutinize tumor mutational burden predictability in head and neck squamous cell carcinoma patients treated with immunotherapy

Mario Sánchez-Canteli

doi:10.17605/OSF.IO/7GMDC

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First meta-analysis to scrutinize tumor mutational burden predictability in head and neck squamous cell carcinoma patients treated with immunotherapy

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Mario Sánchez-Canteli

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Description: The tumor mutational burden (TMB) has been demonstrated to predict the response to immune checkpoint inhibitors (ICIs) in various cancers. However, the role of TMB in head and neck squamous cell carcinoma (HNSCC) has not yet been specifically addressed. Since HNSCC patients exhibit a rather limited response to ICIs, there is an unmet need to develop predictive biomarkers to improve patient selection criteria and the clinical benefit of ICI treatment.

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First meta-analysis to scrutinize tumor mutational burden predictability in head and neck squamous cell carcinoma patients treated with immunotherapy

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