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Description: Open data for the project 'Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia'. Here, we observe typical patterns of lesion, structural disconnection, and functional disconnection in a sample of patients with semantic aphasia following left hemisphere stroke. We observe degrees of damage to relevant functional networks, and map damage onto both semantic impairment and dysexecutive symptoms as measured by the Brixton Spatial Anticipation Test.