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This projects has two aims. First, we examine whether the current evaluation process of the FDA leads to psychotropic drugs (i.e., antidepressants, antipsychotics, and ADHD medication) supported by substantial evidence (at the time of approval). Second, we determine whether there are systematic differences in strength of evidence, trial characteristics, and number of trials for psycho-active drugs across mental disorders and examine whether these potential differences are reflected in the associated evidence load.