Main content

  1. M. Danica San Juan
  2. Daniel Katz
  3. Scott Perkins
  4. Leah Burgess
  5. Ronald Cowan
  6. H. Charles Manning
  7. Michael Nickels
  8. Daniel Claassen
  9. David H. Zald

Date created: | Last Updated:


Creating DOI. Please wait...

Create DOI

Category: Project

Description: Here, we collected PET measures of DAT availability (BPND) using the tracer 18F-FE-PE2I in 47 healthy adult subjects and examined relations between BPND in striatum, including its subregions: caudate, putamen, and ventral striatum (VS), and trait impulsivity (Barratt Impulsiveness Scale: BIS-11) and novelty seeking (Tridimensional Personality Questionnaire: TPQ-NS), controlling for age and sex. Striatal DAT BPND in each subregion was negatively related to total BIS-11 with VS DAT BPND significantly associated with BIS-11 motor impulsivity (e.g., taking actions without thinking) after correction for multiple comparisons. VS DAT BPND explained 13.2% of the variance in motor impulsivity. Our data demonstrate that DAT availability in VS is negatively related to impulsivity, and suggest a particular influence of DAT regulation of dopamine signaling in VS on acting without deliberation (BIS motor impulsivity).


Loading files...


Recent Activity

Loading logs...