Transdiagnostic phenotyping reveals a range of metacognitive deficits associated with compulsivity

Contributors:

Date created: | Last Updated:

: DOI | ARK

Creating DOI. Please wait...

Create DOI

Category: Project

Description: Recent work suggests that obsessive-compulsive disorder (OCD) is underpinned by a breakdown in the relationship between explicit beliefs about how the world works (i.e. confidence about states) and updates to behaviour. The present study aimed to test the precise computations that underlie this disconnection and ascertain their specificity to OCD symptoms. We phenotyped a large general population sample (N = 437), who also completed a predictive inference task and found that decreases in action-confidence coupling were not only associated with OCD symptoms, but also several other clinical phenotypes (6/9 corrected for multiple comparisons). This non-specific pattern was explained by a transdiagnostic compulsive symptom dimension. Action-confidence decoupling in high compulsives was associated with a marked inability to update confidence estimates (but not behaviour) according to unexpected outcomes, uncertainty and positive feedback. Our findings suggest that compulsive behaviour may be explained by difficulty in building an accurate explicit model of the world.

License: CC-By Attribution 4.0 International

Wiki

A preprint of this work can be found here at BioRxiv.

Files

Loading files...

Citation

Tags

Recent Activity

Loading logs...

OSF does not support the use of Internet Explorer. For optimal performance, please switch to another browser.
Accept
This website relies on cookies to help provide a better user experience. By clicking Accept or continuing to use the site, you agree. For more information, see our Privacy Policy and information on cookie use.
Accept
×

Start managing your projects on the OSF today.

Free and easy to use, the Open Science Framework supports the entire research lifecycle: planning, execution, reporting, archiving, and discovery.