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In this study, we compared change in 18F-Fallypride binding potential (BPND) on oral d-amphetamine relative to placebo as a measure of dopamine release in male and female subjects across two independent Positron Emission Tomography (PET) datasets. We found no evidence of consistent sex difference sin our PET measure of dopamine release. The raw data used in our publication are available here for others to analyze and use. Adding our results to other studies will improve the ability to test for more specific effects (hormone levels, birth control status, menopause) on dopamine release in healthy humans.