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<p>Target of replication: <em>A priori</em> experimental protocols, materials, and confirmatory analysis plans were peer reviewed, <a href="https://osf.io/j9bnk/" rel="nofollow">pre-registered</a>, and published by <a href="https://elifesciences.org/articles/13620" rel="nofollow"><em>eLife</em></a>.</p> <p>This component includes all primary and QC data for the replication of <a href="https://www.nature.com/articles/nature11005" rel="nofollow">Garnett et al. 2012</a>. This experiment analyzed the sensitivity of Ewing’s sarcoma cell lines to PARP inhibition.</p> <h3>Contents</h3> <p><a href="https://osf.io/psy97/wiki/home/" rel="nofollow">Figures component</a> contains a visualization of the results. These figures are the same as can be found in the Replication Study and include: - <strong>Figure 1. Sensitivity of Ewing’s sarcoma cell lines to olaparib</strong>, which is the vizualization of the Colony formation assays - <strong>Figure 1 - figure supplement 1</strong>. Repeat of colony formation assay, which displays the repeat of the Colony formation assay</p> <p><a href="https://osf.io/ujg7t/wiki/home/" rel="nofollow">Data Component</a>, contains data generated from the experimental work. Csv files containing the data used in the analysis of protocol 1, which assesses the Sensitivity of Ewing’s sarcoma cell lines to olaparib, can be found <a href="https://osf.io/sqzx2/" rel="nofollow">here</a>. </p> <p><a href="https://osf.io/pfh3x/wiki/home/" rel="nofollow">Statistical Analysis Component</a>, contains the R scripts used for the analysis.</p> <p><a href="https://osf.io/x4zwb/wiki/home/" rel="nofollow">Cell line quality Control data</a> includes results confirming the cell line was free of mycoplasma contamination as well as STR DNA profiling.</p>
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