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Description: Tramadol is one of the most prescribed painkillers in the world. It is a synthetic opioid that is an excellent alternative to morphine and its derivatives in African countries. It is an essential drug due to its low cost and constant availability. However, the health consequences of tramadol use in illicit trafficking, like those caused by fentanyl and methadone in North America, are poorly documented. This scoping review aims to provide an understanding of the nature and extent of the use and health consequences of the Non-Medical Use (NMU) of tramadol in Africa to guide future in-depth research on the phenomenon.

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