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Date created: 2021-04-12 09:47 AM | Last Updated: 2022-11-15 03:54 PM

Category: Project

Description: Transcranial direct current stimulation (tDCS) is increasingly used to investigate the involvement of the cerebellum in a variety of brain functions and pathologies. However, heterogeneity and small effect sizes remain a common issue. One potential cause may be interindividual variability of the electric fields induced by tDCS. Here, we compared electric field distributions between two conventionally used electrode montages (i.e., one placing the return electrode over the ipsilateral buccinator muscle and one placing the return electrode [25 and 35 cm² surface area, respectively] over the contralateral supraorbital area) and six alternative montages (electrode size: 9 cm²) targeting the right posterior cerebellar hemisphere at 2 mA. Interindividual and montage differences in the achieved maximum field strength and focality were evaluated in twenty head models and the effects of individual differences in scalp-cortex distance were examined. Results showed that while maximum field strength was comparable for all montages, focality was substantially improved for the alternative montages placing the electrodes below occipital electrode positions. Our findings suggest that compared to several conventional montages extracerebellar electric fields are significantly reduced by placing smaller electrodes in closer vicinity of the targeted area.

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This repository contains the data associated with the simulations as well as an analysis script documenting the reported results. Individual simulation output can be requested from Jana Klaus at j.klaus@uu.nl.

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