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Description: Few studies have synthesized the current scientific knowledge available on anxiety and depression in gifted individuals. In the present multilevel meta-analysis, we collected data from 37 studies published between 1996 and 2020 with the aim of investigating heterogeneity as well as potentially moderating variables such as age, gender, type of identification and recruitment of giftedness, type of anxiety, study location, type and year of publication, and educational accompaniment. In contrast to the previous meta-analysis (Martin et al., 2010), we find a small effect size g = -0.14, 95% CI [-0.27, 0.01], and not significant. However, we find a similar effect size at the depression level g = -0.14, 95% CI [-0.29, 0.00], not significant. The moderator analysis indicates significantly lower performance anxiety among the gifted, but a higher level of anxiety among the gifted in the French studies. No moderating effect was found for depression measures.