The Impact of Reproductive Aging on the Human Hippocampus and Spatial Navigation Strategy

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Abstract: Menopause is marked by a 90% decline in endogenous ovarian hormone production. Among brain regions affected by this reproductive aging event is the hippocampus (HC), which is responsible for encoding flexible and efficient spatial navigation. In rodents, estradiol’s influence on HC structure has been marked by changes in dendritic spine density and ultimately changes in behavior in spati...

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