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This project contains all information pertaining to the replication of experiments from “A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations” published in *Cell* in 2010 ([Sharma et al., 2010][1]). Experimental work began with preliminary outcomes although experiments were not completed. The preliminary outcomes were included in the summary paper "Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology" ([Errington et al., 2021][2]). <br> Also, explore the Registered Report and materials related to the Registered Report [here][3]. <br> **Data and Material Availability**: All other associated data, protocols, analysis scripts, and other digital materials are available within this OSF project. **Experiments replicated**: Reproduce and explore the figures, analyses, data, and methods generated in this replication attempt. - [Preliminary study of growth characterisitics of PC9 cells and PC9 “drug-tolerant persisters” (DTPs)][4] <br> Questions about the project can be directed to contact+rpcb@cos.io. [1]: https://doi.org/10.1016/j.cell.2010.02.027 [2]: https://doi.org/10.7554/eLife.73430 [3]: https://elifesciences.org/articles/09462 [4]: https://osf.io/ynsfm/wiki/home