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<p>Previous research has demonstrated that concurrent use of alcohol and cannabis is highly prevalent and is associated with a host of negative consequences. The current study examined the effects of alcohol administration on the urge to use marijuana and sex differences in a sample (N = 37, 46% females) of non-treatment-seeking heavy drinkers who reported marijuana use in the last six months. Alcohol was administered intravenously. Participants rated their urge to use marijuana at baseline and at brACs .02, .04, and .06 g/dl on a 10-point Likert Scale. The Time Line Follow Back, AUDIT, and CUDIT were assessed to determine alcohol and marijuana problems. Analyses revealed a significant Sex × Alcohol interaction (β=1.19, SE=0.59, t=2.03, p &lt;.05), as well as a main effect of sex (β=-1.62, SE=0.74, t=-2.18, p &lt;.05) and a main effect of alcohol (β=-1.15, SE=0.41, t=-2.78, p &lt;.05). These findings revealed that craving for marijuana escalated for males when alcohol increased relative to females. If these results are supported by future studies, they may elucidate unique mechanisms by which men may be more vulnerable to the effects of alcohol as a trigger to use marijuana.</p>
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