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Description: Abstract Background: Exercise prescription is a safe solution for disease prevention that enables physicians to instruct their patients to implement exercise as an important part of disease management and treatment. As clinical provision is the primary and front-line service in the healthcare system for the outpatient, exercise prescription in the clinical provision system will improve patients’ life quality and fitness levels. Objective: A scoping review of this research area would provide researchers, healthcare practitioners and policy-makers with an overview and the evidences of the current scientific literature to support to add exercise prescription on the non-communicable diseases clinical care service. Methods: Systematic search of PubMed, Web of Science, MEDLINE, EMBASE, ScienceDirect and reference lists will manually be searched. The literature searching was combined on both SPIDER and PICO tools for qualitative, quantitative studies and mix-study design studies to meet our mix-method research design. The inclusion criteria would be articles with the target patients with non-communicable diseases, investigated exercise interventions, or the comparison between two studied interventions; it would be articles which contain information answering our research question. Results: The methodological framework will be based on PRISMA Extension for scoping reviews (PRISMA-ScR): checklist and Explanation. Data extraction will be performed using EndNote 2.0 software and the data charts for a numerical analysis and a thematic summary. Conclusions: This scoping review summarizes the current evidence base and provide validated key findings that can be used in practice to enhance the implementation exercise prescription into the clinical service for the patients with non-communicable diseases. We hope this scoping review will contribute to the patients and clinical decision making and aid clinical practice guidelines and policy formation. Besides, translated the evidences to such as a healthcare pathway or guideline and policy.