Background: Post-stroke upper limb (UL) motor recovery is associated with adaptive neuroplasticity and motor learning. Factors affecting motor learning and adaptive neuroplasticity include the presence of genetic polymorphisms. However, the implications of genetic polymorphisms on UL motor recovery have not yet been completely elucidated. are unclear. Objectives: Using a systematic review and meta-analyses (if applicable), we will examine the influence of genetic polymorphism on post-stroke UL motor recovery. Methods: MEDLINE and EMBASE databases and Google Scholar repository will be searched using a combination of keywords related stroke, upper limb, genetic polymorphisms and outcomes. Two reviewers will first screen the titles and abstracts. Following this step, full-texts of the articles will be screened to determine eligibility criteria. Publications that describe the impact of genetic polymorphisms on post-stroke upper limb motor improvement assessed using clinical outcome measures will be included. For each included publication, information on number of participants with the polymorphisms, details on the intervention provided, outcomes used, timing of assessments and results will be collected. We will use the Downs and Black questionnaire to assess the quality of the included articles. If two or more studies assess the impact of the polymorphism on upper limb motor recovery using the same outcome measure, we will perform a meta-analysis. Discussion: This systematic review will help delineate the impact of genetic polymorphisms on UL motor improvement. Better recognition of the impact can help in identification and selection of best rehabilitation options to maximize motor improvement for individuals with genetic polymorphisms that have sustained a stroke