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Evaluating modified diets and dietary supplement therapies for reducing muscle lipid and improving muscle function in neurofibromatosis type 1 (NF1)
- Aaron Schindeler
- Emily Vasiljevski
- Thusita Rupasinghe
- Ute Roessner
- Matthew Summers
- Peter Houweling
- David Little
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Description: A diet enriched for medium chain fatty acids and supplemented with L-carnitine has been shown to partially rescue a murine model of NF1 muscle weakness. This model features intramyocellular lipid accumulation. In this study we aim to examine the relative importance specific components of the aforementioned intervention as well as the time frame for therapeutic efficacy and phenotypic relapse after the cessation of therapy.
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