Psychological research is rife with inappropriately concluding “no effect” between predictors and outcome in regression models following statistically nonsignificant results. This approach is methodologically flawed, however, because failing to reject the null hypothesis using traditional, difference-based tests does not mean the null is true. Using this approach leads to high rates of incorrect conclusions which flood psychological literature. This paper introduces a novel, methodologically sound alternative. In this article, we demonstrate how to apply equivalence testing to evaluate whether a predictor (measured in standardized or unstandardized units) has a negligible association with the outcome in multiple linear regression. We constructed a simulation study to evaluate the performance of two equivalence-based methods and compared it to the traditional test. The use of the proposed negligible effect testing methods is illustrated in this paper using functions from the negligible R package along with examples from the literature and recommendations for results reporting and interpretations are discussed.