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To address an apparent gap in the availability of appraisal tools to facilitate consistent, comprehensive, and exacting peer-review of in vitro studies, we are developing a new tool “PRIVAT” (Peer-Review In Vitro Appraisal Tool). The methodology for developing PRIVAT includes: - a systematic search for existing critical appraisal tools and reporting checklists for in vitro study designs; - the creation of an item bank of study appraisal criteria for informing the future development of critical appraisal tools; - designing a straw man tool from the item bank; - analysing the straw man tool via a Delphi process to produce a final working version of PRIVAT.
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