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Description: Background: Urinary tract infections (UTIs) are a serious health problem that affects millions of people each year. Urinary tract infections are the second most common type of infection in the body. One of the causes of infection in the urinary tract is caused by microorganisms such as Pseudomonas aeruginosa. The pathogenic potential was proved by their frequent isolation from clinical samples and association with diseases. from various clinical samples and perform antimicrobial susceptibility testing (AST) by Vitek. Methodology: This study was conducted to investigate the prevalence of antibiotic resistance among Pseudomonas aeruginosa bacteria isolated from the urine of patients Suffering from UTI in Karbala governorate. (100) isolated samples of Pseudomonas aeruginosa were isolated from the urine of UTI patients with ages ranging from 5 to 65 years for both sexes and the samples were diagnosed based on a number of biochemical tests and sensitivity test using VITEK 2 system technology. Results: In this study, it was found that 100 Pseudomonas aeruginosa bacterial isolate (75% female and 25% male) of patients with urinary tract infection, Pseudomonas aeruginosa showed a high resistance to antibiotics. The study also showed that the percentage of adult females with urinary tract infection due to Pseudomonas aeruginosa is higher than males, reaching 75%. The most effective antimicrobial against Pseudomonas aeruginosa were ( colistin sulphate and gentamicin). While a high resistance rate towards the antibiotics ( Ceftazidime , ciprofloxacin , levofloxacin , amikacin , Tetracycline , Imipenem , Meropenem , Trimethoprim , Piperacillin). Conclusion: It was concluded that Pseudomonas aeruginosa, which was increase resistant rate to antibiotics and this is observed through this study against antipseudomonal drugs indicates the need to develop targeted approaches to help control antimicrobial resistance.