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Assessing the isocitrate-dependent NADPH production and alpha-ketoglutarate-dependent NADPH consumption of wild-type or R172K mutant IDH2  /

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Affiliated institutions: Center For Open Science

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Figure 1. Isocitrate-dependent NADPH production and alpha-ketoglutarate-dependent NADPH consumption of wild-type or R172 mutant IDH2. Number of mice: (A) A549 tumors: n=14 (vehicle), n=13 (cimetidine), n=4 (doxorubicin) (B) ACHN tumors: n=15 (vehicle), n=15 (cimetidine). Two-tailed Welch’s t-test on Day 11 relative volumes between vehicle or doxorubicin treated A549 tumors; t (6.73) = 2.68, uncorr…

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