**Desert dust** and sandstorms are recurring environmental phenomena that are reported to produce serious *health risks* worldwide. This **scoping review** was conducted to identify the most likely *health effects of desert dust* and sandstorms and the **methods used to characterize desert dust exposure** from the existing epidemiological literature. We systematically searched **PubMed/MEDLINE, Web of Science, and Scopus** to identify studies that reported the effects of desert dust and sandstorms on human health. Search terms referred to desert dust or sandstorm exposure, names of major deserts, and health outcomes. Health effects were cross-tabulated with study design variables (e.g., epidemiological design and methods to quantify dust exposure), desert dust source, health outcomes and conditions. We identified **204 studies** that met the inclusion criteria for the scoping review. More than half of the studies (52.9%) used a time-series study design. However, we found a substantial variation in the methods used to identify and quantify desert dust exposure. The binary metric of dust exposure was more frequently used than the continuous metric for all desert dust source locations. Most studies (84.8%) reported significant associations between desert dust and adverse health effects, mainly for respiratory and cardiovascular mortality and morbidity causes. Although there is a **large body of evidence** on the health effects of desert dust and sandstorms, the existing **epidemiological studies have significant limitations** related to exposure measurement and statistical analysis that potentially contribute to inconsistencies in determining the effect of desert dust on human health.