Heterozygous mutations in VCP/p97 and resistance to VCP inhibitors

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Resistance to CB-5083 was generated by gradual exposure to CB-5083 in OVSAHO ovarian cancer cells (PMID: 29367883). RNA sequencing was performed in triplicate between parental and resistant cells to determine differences in gene expression and mutations between parental and resistant cells. Raw sequencing data can be accessed at the EBI ArrayExpress using the dataset ID: E-MTAB-7328

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