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The Lew Lab at Washington University in St. Louis
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Description: Welcome to our home on OSF. Summaries of our research projects. Links to supplementary data from our publications.
Find our research summaries in the "Files" section. View supporting data for our various publications by jumping to the projects listed as "Components". Access our software repository on GitHub.
To learn more, jump to our lab's homepage, read an overview of our research, or view our publication list.
Highlights of our single-molecule orientation-localization technology:
Files
Files can now be accessed and managed under the Files tab.
Citation
Components
Single-molecule orientation localization microscopy of amyloid fibrils
Single-molecule orientation-localization data, animations, and interactive demonstrations accompanying our manuscript:
"Single-molecule orientation lo...
RoSE - Robust Statistical Estimation
Source code and ground-truth molecule brightnesses and positions, simulated noisy images, and brightness and localization data output by RoSE and RoSE...
Single-molecule 3D orientation imaging reveals nanoscale compositional heterogeneity in lipid membranes
Data accompanying "Single‐molecule 3D orientation imaging reveals nanoscale compositional heterogeneity in lipid membranes."
Lu, J., Mazidi, H., Ding,...
WIF - Single-molecule localization confidence
Data and software accompanying "Quantifying accuracy and heterogeneity in single-molecule super-resolution microscopy," Nature Communications (2020).
...
Single-Molecule Localization Microscopy of 3D Orientation and Anisotropic Wobble using a Polarized Vortex Point Spread Function
Data accompanying our manuscript "Single-Molecule Localization Microscopy of 3D Orientation and Anisotropic Wobble Using a Polarized Vortex Point Spre...
Resolving the Three-Dimensional Rotational and Translational Dynamics of Single Molecules Using Radially and Azimuthally Polarized Fluorescence
Data accompanying the manuscript “Resolving the three-dimensional rotational and translational dynamics of single molecules using radially and azimuth...
Dipole spread function engineering for simultaneously measuring the 3D orientation and 3D localization of dipole-like emitters
Data accompanying the manuscript, “Dipole-spread-function engineering for simultaneously measuring the 3D orientations and 3D positions of fluorescen...
Deep-SMOLM: Deep Learning Resolves the 3D Orientations and 2D Positions of Overlapping Single Molecules with Optimal Nanoscale Resolution
Data and visualizations accompanying "Deep-SMOLM: Deep Learning Resolves the 3D Orientations and 2D Positions of Overlapping Single Molecules with Opt...
Towards optimal point spread function design for resolving closely spaced emitters in 3D
Supporting data for our manuscript "Towards optimal point spread function design for resolving closely spaced emitters in three dimensions," Opt. Expr...
Six-Dimensional Single-Molecule Imaging with Isotropic Resolution using a Multi-View Reflector Microscope
Data supporting the manuscript: Zhang, O., Guo, Z., He, Y. et al. Six-dimensional single-molecule imaging with isotropic resolution using a multi-view...
Single-Molecule Electrochemical Imaging Resolves the Midpoint Potentials of Individual Fluorophores on Nanoporous Antimony-Doped Tin Oxide
Data supporting the manuscript "Single-Molecule Electrochemical Imaging Resolves the Midpoint Potentials of Individual Fluorophores on Nanoporous Anti...
Resolving the nanoscale structure of β-sheet assemblies using single-molecule orientation-localization microscopy
Data and software accompanying the manuscript, "Resolving the nanoscale structure of β-sheet assemblies using single-molecule orientation-localization...
Single-molecule orientation imaging reveals changes in the nano-architecture of amyloid fibrils undergoing growth and decay
Supporting data and code for our manuscript: "Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth a...
Fundamental Limits in Measuring the Anisotropic Rotational Diffusion of Single Molecules
Supporting data and code for the manuscript, "Fundamental Limits in Measuring the Anisotropic Rotational Diffusion of Single Molecules." J. Phys. Chem...
Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates
Data and code accompanying our manuscript:
Tingting Wu, Matthew R. King, Yuanxin Qiu, Mina Farag, Rohit V. Pappu, Matthew D. Lew
bioRxiv 2023.01.26.5...
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