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Early life neuroimmune mechanisms underlying neurodevelopmental outcomes of South African children who are HIV-exposed and uninfected: A longitudinal neuroimaging and neuroinflammatory biomarkers study. /
Study 1: Impact of HIV exposure on child immune trajectories and associations with neurometabolic profiles at age 2 years: a South African birth cohort study
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Description: As a kickstart to my PhD journey, the purpose of this first study is to investigate whether neurodevelopmental outcomes observed in children who are HIV-exposed and uninfected (measured with the Bayley Scales Of Infant and Toddler Development, BSID-III) can be explained through the intermediary influence of altered maternal and child immune profiles, and subsequent neurometabolic ratios, in these children at age two years. Through a longitudinal lens, we aim to delineate trajectories of peripheral blood levels of inflammatory and neuroimmune markers in children who are HEU and their mothers, and identify potential associations with neurometabolic ratios and BSID-III scores.
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