All the experiences of our life build the microscopic details of our brain. In the case of musicians, years of musical training results in some special neurological characteristics. Brain-Computer Interface (BCI) systems collect brain activity, for example derived from motor imagery, by means of an electroencephalogram and then these systems process and transform this physiological signal in order to launch commands which will serve to control a specific device. The improvement of the coordination between hands of pianists suggests that their performance in these systems can be better than other subjects. For this purpose, in this work, a group of pianists has been subjected to a BCI handling experiment, controlled by means of imaginary hand movements, and then compared with another control group, over three sessions. The performances achieved by the former in the last trial (74.69%), compared to the latter (63.13%), suggest that extended musical training can improve BCI control by means of motor imagery.