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Effect of muscular exercise on patients with muscular dystrophy: a systematic review and meta-analysis of the literature
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Description: Muscular dystrophy causes weakness and muscle loss. The effect of muscular exercise in these patients remains controversial. We assess the effects of muscular exercise versus no exercise in patients with muscular dystrophy. We performed a comprehensive systematic search in the Medline, Embase, Web of Science, Scopus, and Pedro databases. We included randomized clinical trials (RCTs) that reported the effect of muscular exercise on muscle strength, endurance during walking, motor abilities, and fatigue. Mean difference (MD) and 95% confidence intervals (CI) were used to quantify the effect associated with each outcome. We performed meta-analyses and trial sequential analyses (TSA) and used GRADE to rate the overall certainty of evidence.