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<p>Target of replication: <em>A priori</em> experimental protocols, materials, and confirmatory analysis plans were peer reviewed, <a href="https://osf.io/nj8wb/" rel="nofollow">pre-registered</a>, and published by <a href="https://elifesciences.org/articles/04024" rel="nofollow"><em>eLife</em></a>.</p> <p>This component includes all primary and QC data for the replication of <a href="http://www.cell.com/cell/fulltext/S0092-8674(12)01057-4" rel="nofollow">Lin et al. 2012</a>. This experiment included the Western blot of c-Myc reactivation in tetracyclic-repressible system and total RNA expression during c-Myc re-activation.</p> <h3>Contents</h3> <p><a href="https://osf.io/ksd5y/wiki/home/" rel="nofollow">Figures component</a> contains a visualization of the results. These figures are the same as can be found in the Replication Study and include Figure 1 displaying the Western blot re-activation results.</p> <p><a href="https://osf.io/ujg7t/wiki/home/?edit&view&menu" rel="nofollow">Data Component</a>, contains data generated from the experimental work. Csv files containing the data used in the analysis of protocol 1, which assesses the relative levels of c-Myc protein after re-induction, can be found <a href="https://osf.io/7xjpk/" rel="nofollow">here</a> and the raw data <a href="https://osf.io/ujg7t/files/" rel="nofollow">here</a> in the "Protocol 1" folder. The Csv file that contains the data used in the analysis of protocol 2, which assesses relative levels of total RNA before and after re-induction of c-Myc, can be found <a href="https://osf.io/72czk/" rel="nofollow">here</a> and the raw data <a href="https://osf.io/ujg7t/files/" rel="nofollow">here</a> in the "Protocol 2" folder.</p> <p><a href="https://osf.io/stfj5/wiki/home/" rel="nofollow">Statistical Analysis Component</a>, contains the R scripts used for the analysis.</p> <p><a href="https://osf.io/e6ftz/wiki/home/" rel="nofollow">Cell line quality Control data</a> includes results confirming the cell line was free of mycoplasma contamination as well as STR DNA profiling.</p>
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