Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all primary and QC data for the replication of [Lin et al. 2012][3]. This experiment included the Western blot of c-Myc reactivation in tetracyclic-repressible system and total RNA expression during c-Myc re-activation. ### Contents ### [Figures component][4] contains a visualization of the results. These figures are the same as can be found in the Replication Study and include Figure 1 displaying the Western blot re-activation results. [Data Component][5], contains data generated from the experimental work. Csv files containing the data used in the analysis of protocol 1, which assesses the relative levels of c-Myc protein after re-induction, can be found [here][6] and the raw data [here][7] in the "Protocol 1" folder. The Csv file that contains the data used in the analysis of protocol 2, which assesses relative levels of total RNA before and after re-induction of c-Myc, can be found [here][8] and the raw data [here][9] in the "Protocol 2" folder. [Statistical Analysis Component][10], contains the R scripts used for the analysis. [Cell line quality Control data][11] includes results confirming the cell line was free of mycoplasma contamination as well as STR DNA profiling. [1]: https://osf.io/nj8wb/ [2]: https://elifesciences.org/articles/04024 [3]: http://www.cell.com/cell/fulltext/S0092-8674(12)01057-4 [4]: https://osf.io/ksd5y/wiki/home/ [5]: https://osf.io/ujg7t/wiki/home/?edit&view&menu [6]: https://osf.io/7xjpk/ [7]: https://osf.io/ujg7t/files/ [8]: https://osf.io/72czk/ [9]: https://osf.io/ujg7t/files/ [10]: https://osf.io/stfj5/wiki/home/ [11]: https://osf.io/e6ftz/wiki/home/