For detailed instructions on how to set-up COSMOS on a high performance computing cluster, please download the
01_COSMOS_setup.zip, unzip and follow the instructions provided in the document "README_COSMOS_setup.docx". This data package also contains Excel spreadsheets listing the exact COSMOS run settings used to generate the different Degrader- and GDC0068-specific networks.
The input data used for COSMOS were generated as part of the RNAseq and metabolomics analyses provided in the subcomponent "RNAseq_metabolomics". For convenience, the relevant scripts have also been provided in the subdirectory "input_file_generation_example_code".
To reproduce the COSMOS summary statistics provided in Fig.3, please download "COSMOS_network_analysis_code_for_publication_checked.zip".
For issues/questions, please contact Dr Ralitsa Madsen (r.madsen@ucl.ac.uk).