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Test of association between DRD2/ANKK1 TaqIA allele status and striatal dopamine D2/3 receptor availability in alcohol dependence
- Eva Friedel
- Gianna Spitta
- Lena Fliedner
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Description: We investigated the DRD2/ANKK TaqIA allele status (rs1800497) and the striatal dopamine 2 and 3 availability via 18F-fallypride PET in 13 alcohol dependent (AD) patients and 17 gender matched healthy controls (HC). Age and smoking status were included as covariates. Contrary to our expectations, no association of the TaqIA allele status and the striatal dopamine D2/3 receptor availability of AD compared to HC was found. Among other factors, this may be explained by the relatively small sample size (N=30). To our knowledge, however, this is the first in vivo study investigating dopamine receptor availability and genetics in AD.
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