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<p>Obsessive-compulsive disorder (OCD) is prevalent among individuals with schizophrenia (Buckley et al., 2009). Patients also commonly report obsessive-compulsive symptoms, which are associated with poorer cognition and prognosis (Ongur & Goff, 2005). Although obsessive-compulsive symptoms may emerge early in the development of schizophrenia (Eisen et al., 1997), little is known about the clinical and neurobiological features of youth at clinical high risk for psychosis (CHR) with comorbid OCD. Using data from a large multisite study, we examined: 1) differences in psychotic symptoms and role functioning, 2) EEG measures of cognitive dysfunction with known sensitivity to psychosis, and 3) relative risk of future psychotic disorder diagnosis among CHR youth with (OCD+) and without (OCD-) comorbid OCD. Preliminary analyses indicate that relative to OCD-, OCD+ CHR youth had more severe symptoms and poorer prognosis but intact EEG measures of cognition. OCD+ and OCD- did not differ in role function. Results revealed clinical and EEG profiles of CHR youth that differed by OCD status, suggesting that CHR youth with OCD may have distinct mechanisms underlying their psychosis risk.</p>
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