Main content

Home

Menu

Loading wiki pages...

View
Wiki Version:
## Oxford MM templates ## We constructed a multimodal template from UK Biobank individuals in the 50-55 year age range, the Oxford-MM-1 (OMM-1), and one multimodal age-dependent template (ADT) for each year in the 45-81 age range. All templates are fully unbiased with respect to shape and internal consistency is ensured by jointly informing the construction process with T1, T2-FLAIR and DTI data. ADTs were derived with a Gaussian Process (GP), which models the change in average brain shape with age in 37,330 individuals. Although it may be sufficient to simply use the OMM-1 directly for different study populations, we provide the GP-derived spatial mapping (deformation field) between the OMM-1 and each ADT. Should the use of an ADT be preferred (e.g., the 80 year ADT for an older population study), then our template provides a natural way to compare results with those from other studies using the generic OMM-1, as well as making atlases defined in generic OMM-1 space available in any ADT. More information about the templates can be found in the respective sub-projects. All templates found here are also available on Gitlab: OMM-1: https://git.fmrib.ox.ac.uk/fsl/oxford-mm-templates OMM-1 ADTs: https://git.fmrib.ox.ac.uk/cart/oxford-mm-ad-templates Our general pipeline for cross-sectional template construction can be downloaded from Gitlab: https://git.fmrib.ox.ac.uk/cart/mm-template-construction ### Oxford-MM-1 ### Online viewer (Firefox, or Google Chrome recommended): https://open.win.ox.ac.uk/pages/fsl/oxford-mm-templates/ ![Oxford-MM-1 T1, T2 FLAIR, and DTI volumes][1]*Oxford-MM-1 T1, T2 FLAIR, and DTI volumes* ![Oxford-MM-1 T2 FLAIR overlayed with DTI volume][2]*Oxford-MM-1 T2 FLAIR overlayed with DTI volume* Version 1 of our multimodal asymmetric template with its T1, T2 FLAIR and DTI volumes. It was constructed from **240 UK Biobank individuals uniformly sampled from the age range 50-55 years (50% female/male)**. We believe a template from this age range will be useful for a wealth of studies. Note that the template was **rigidly transformed to MNI space** to capture the population’s average brain shape and size, and avoid the introduction of unrepresentative scaling effects. When using this template please cite:<br> **Arthofer, C., Smith, S.M., Jenkinson, M., Andersson, J., Lange, F. Multimodal MRI template construction from UK Biobank: Oxford-MM-0. (2021). Organisation for Human Brain Mapping (OHBM)** [1]: https://git.fmrib.ox.ac.uk/fsl/oxford-mm-templates/-/raw/main/Oxford-MM-1/oxford-mm-1_overview.jpg [2]: https://git.fmrib.ox.ac.uk/fsl/oxford-mm-templates/-/raw/main/Oxford-MM-1/oxford-mm-1_T2+tensor.png ### Oxford-MM-1 Age-Dependent Templates (ADTs) ### ![Oxford-MM-1 ADTs shown in steps of 5 years - rows from top to bottom show the T1, T2-FLAIR, and DTI volumes, V1 transparancy-modulated by FA overlayed on the T2-FLAIR and a zoomed-in part, the log-Jacobian determinant map showing the corresponding distortion with respect to the OMM-1][3]*Oxford-MM-1 ADTs shown in steps of 5 years - rows from top to bottom show the T1, T2-FLAIR, and DTI volumes, V1 transparancy-modulated by FA overlayed on the T2-FLAIR and a zoomed-in part, the log-Jacobian determinant map showing the corresponding distortion with respect to the OMM-1* ADTs associated with the OMM-1 contain the same volumes (T1, T2-FLAIR, DTI), which were also used to drive their construction. The imaging data from 37,330 UK Biobank individuals was used for modelling the change with age using a GP. Please see the sub-project for more information. When using these templates please cite:<br> **Arthofer, C., Smith, S.M., Douaud, G., Bartsch, A., Andersson, J., Lange, F. Age-dependent multimodal MRI template construction from UK Biobank, (2022). 28th Annual Meeting of the Organisation for Human Brain Mapping (OHBM)** **Arthofer, C., Smith, S.M., Douaud, G., Bartsch, A., Andersson, J., Lange, F. Assessing the impact of age-specific template selection on spatial normalization. (2023). 29th Annual Meeting of the Organisation for Human Brain Mapping (OHBM)** [3]: https://git.fmrib.ox.ac.uk/cart/oxford-mm-ad-templates/-/raw/main/Oxford-MM-1_ADTs/age-dependent_templates.jpg DOI 10.17605/OSF.IO/S9GE4 Copyright, 2022, University of Oxford. All rights reserved
OSF does not support the use of Internet Explorer. For optimal performance, please switch to another browser.
Accept
This website relies on cookies to help provide a better user experience. By clicking Accept or continuing to use the site, you agree. For more information, see our Privacy Policy and information on cookie use.
Accept
×

Start managing your projects on the OSF today.

Free and easy to use, the Open Science Framework supports the entire research lifecycle: planning, execution, reporting, archiving, and discovery.