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<p>Presentation Abstract:</p> <p>Alterations in subcortical structures have been found in individuals with schizophrenia and across the psychosis spectrum. Repeated studies have shown hippocampal volume reduction in schizophrenia patients. On the low end of the spectrum, hippocampal and thalamic volume reduction was seen in clinical high-risk individuals compared to healthy controls (Harrisberger, 2016). Our study focuses one step lower on the spectrum and examines the subcortical volumes of healthy adults who endorse having psychotic-like experiences (PLE). Using the Human Connectome Project data, 104 adults with high PLEs (endorsing &gt;2 thought problems on Achenbach Self Report), and 208 matched controls were selected. MRI data was analyzed in FreeSurfer to obtain subcortical structure volumes. We hypothesized lower hippocampal and thalamic volume in high PLE individuals relative to controls. Analyses showed no difference in hippocampal volume (p = n.s) nor other subcortical structures in high PLE individuals relative to controls. Potential future research might focus on understanding the emergence of behavioral alterations in high PLE individuals at the absence of anatomical alterations in these regions.</p>
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