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Description: We recorded from the full dorso-ventral extent of mPFC in each of 8 rats, as they performed a complex economic decision task. These data revealed four distinct functional domains within mPFC that closely mirrored anatomically-identified subregions, including novel evidence to divide prelimbic cortex into dorsal and ventral components. We found that dorsal aspects of mPFC (ACC, dPL) processed information about active decisions, while ventral aspects (vPL, IL) were more engaged in motivational factors. Methods: Neural ensembles recorded from silicon probes in the medial prefrontal regions of 8 rats running the Restaurant Row task with both offer and wait zones. For full methods see Diehl, G. W., & Redish, A. D. (2022). Differential processing of decision information in subregions of rodent medial prefrontal cortex. Usage Notes MATLAB code to open data files is included with the data archive. (Originally analyzed with MATLAB 2017b.)