Andrew Sallans, Partnerships Lead, Center for Open Science Natalie Meyers, E-Research Librarian, University of Notre Dame The Center for Open Science (COS) was founded as a non-profit technology start-up in 2013 with the goal of improving transparency and reproducibility by connecting the scholarly workflow. COS achieves this goal through the development of a free, open source Web application called the Open Science Framework (OSF), providing features like file sharing and citing, persistent urls, provenance tracking, and automated versioning. The OSF goes further by simplifying workflow transitions through application programming interface (API) add-on connections to 3rd party services. Initial connections include: Figshare, GitHub, Amazon S3, Dropbox, Box Dataverse, Google Drive, Mendeley and Zotero. Community developers are now working on the addition of 19 new add-ons reaching many new parts of the scholarly workflow. In June 2015, COS and the University of Notre Dame began conversations around opportunities to integrate the OSF and institutional research support services to provide users with a more seamless experience. This session will revisit the core OSF architecture and the problems that it solves, and then explore how this infrastructure can support the institutional research mission, demonstrated through specific examples from the University of Notre Dame. COS is funded through the generosity of grants from the Laura and John Arnold Foundation, the John Templeton Foundation, the Alfred P. Sloan Foundation, the Association of Research Libraries, the National Institutes of Health, and others.