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<p><strong>Figure 2. Tumor weight following treatment.</strong> Mice harboring orthotopic 22Rv1 human prostate tumors were intravenously injected with PBS alone (PBS), 1 mg/kg DOX and PBS (DOX + PBS), or 1 mg/kg DOX and 4 µmol/kg iRGD (DOX + iRGD). Mice were treated every other day for 24 days and 1 hr after the last treatment tumors were harvested and weighed. Means reported and error bars represent s.e.m. Number of mice per condition (n=7; n=21 mice total). One-way ANOVA on tumor weights of all groups; <em>F</em>(2, 18) = 1.58, <em>p</em> = .233. Two-tailed Welch's <em>t</em>-test; <em>t</em>(8.01) = 0.227, <em>p</em> = .826, with <em>a priori</em> alpha level = .05.</p> <p>Access <a href="https://osf.io/r7pc2/" rel="nofollow">full size image</a> and <a href="https://osf.io/tkqyh/" rel="nofollow">R script</a> used to generate this figure. This script will call the <a href="https://osf.io/v6gn8/" rel="nofollow">data</a> directly from the OSF.</p> <p><br></p> <p><strong>Figure 3. Body weight shift during treatment.</strong> Mice bearing orthotopic 22Rv1 human prostate tumors were intravenously injected with PBS alone (PBS), 1 mg/kg DOX and PBS (DOX + PBS), or 1 mg/kg DOX and 4 µmol/kg of iRGD (DOX + iRGD). Mice were treated every other day for 24 days with total body weight measured every four days during the treatment. On day 0 body weight was considered 100% for each animal. Means reported and error bars represent <em>SD</em>. Number of mice per condition (n=7; n=21 mice total). One-way ANOVA on percent body weight shift of all groups on day 24; <em>F</em>(2, 18) = 1.666, <em>p</em> = .217.</p> <p>Access <a href="https://osf.io/phxb3/" rel="nofollow">full size image</a> and <a href="https://osf.io/7vmkd/" rel="nofollow">R script</a> used to generate this figure. This script will call the <a href="https://osf.io/y82jp/" rel="nofollow">data</a> directly from the OSF.</p> <p><br></p> <p><strong>Figure 3 - figure supplement 1. Total body weight during treatment.</strong> This is the same experiment as in Figure 3, but with the mouse weights plotted for each condition instead of body weight shift. Mice bearing orthotopic 22Rv1 human prostate tumors were intravenously injected with PBS alone (PBS), 1 mg/kg DOX and PBS (DOX + PBS), or 1 mg/kg DOX and 4 μmol/kg of iRGD (DOX + iRGD). Mice were treated every other day for 24 days with total body weight measured every four days during the treatment. Means reported and error bars represent <em>SD</em>. Number of mice per condition (n=7; n=21 mice total). One-way ANOVA on area under the curve (AUC) of body weight over the entire curve of all groups; <em>F</em>(2, 18) = 1.072, <em>p</em> = .363.</p> <p>Access <a href="https://osf.io/kznp5/" rel="nofollow">full size image</a> and <a href="https://osf.io/v4w9b/" rel="nofollow">R script</a> used to generate this figure. This script will call the <a href="https://osf.io/y82jp/" rel="nofollow">data</a> directly from the OSF.</p> <p><br> <br></p> <hr> <p><a href="https://osf.io/8xgyc/wiki/home/" rel="nofollow">Statistical Analyses component</a> contains R scripts that were used for the analysis.</p> <hr> <p><a href="https://osf.io/s3h46/wiki/Additional%20figures/" rel="nofollow">Additional figures</a> not included in the <a href="https://osf.io/tuy3e/" rel="nofollow">manuscript</a> were also generated to provide alternative visualization of the data collected.</p>
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