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Characterization of circulating T cells in people with and without Down syndrome
- Paula Araya
- Katherine A. Waugh
- Kelly D. Sullivan
- Nicolás G. Núñez
- Emiliano Roselli
- Keith P. Smith
- Ross E. Granrath
- Angela L. Rachubinski
- Belinda Enriquez Estrada
- Eric T. Butcher
- Ross Minter
- Kathryn D. Tuttle
- Tullia C. Bruno
- Mariana Maccioni
- Joaquín M. Espinosa
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Category: Data
Description: Triplication of human chromosome 21, or trisomy 21 (T21), causes the condition known as Down syndrome (DS). People with DS show a markedly different disease spectrum relative to typical people, being highly predisposed to conditions such as Alzheimer’s disease, while being protected from other conditions, such as most solid malignancies. Interestingly, people with DS are affected by high rates of autoimmune disorders, whereby the immune system mistakenly attacks healthy tissues. We performed an exhaustive characterization of the T cells of people with DS, demonstrating many alterations in this key immune cell type that could explain their high risk of autoimmunity.
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