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Date created: 2021-06-23 04:47 PM | Last Updated: 2021-10-26 03:41 PM

Category: Project

Description: The present meta-analysis aims to examine whether altered fractional anisotropy of the left and right uncinate fasciculus (UF) represent an endophenotype of bipolar disorder (BD). Second, we aim to determine whether altered myelination of the UF may play a role in BD. Lastly, we investigate potential sources of heterogeneity in findings in the UF, such as age, sex ratio, percentage of individuals with BD taking lithium or anti-psychotic medication, percentage of individuals with BD with a lifetime comorbid anxiety disorder, and the diffusion tensor imaging processing pipeline.

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Published article in Journal of Affective Disorders: https://doi.org/10.1016/j.jad.2021.10.045

Preprint: https://doi.org/10.1101/2021.07.06.21260113

PROSPERO pre-registration of the present meta-analysis: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020199563

Parts of this data have been presented at the 2021 Society of Biological Psychiatry Annual Meeting: https://doi.org/10.101…

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at-risk relativesbipolar disorderendophenotypeuncinate fasciculuswhite matter

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