Preclinical Reproducibility and Robustness ------------------------------------------ **About** The [Preclinical Reproducibility and Robustness channel][1] on [*F1000Research*][2] has been created to encourage and facilitate open and transparent publication and discussion of confirmatory and non-confirmatory studies in biomedical research. The raw data for each publication is available here. Read the [Editorial][3] by Guest Editors Bruce Alberts and Alexander Kamb for more details. **Data availability** [Dataset: Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?][4] [Dataset: GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance][5] [Dataset: Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats][6] **Contact us** research@f1000.com [1]: http://f1000research.com/channels/prr [2]: http://f1000research.com/ [3]: http://f1000research.com/articles/5-135/v1 [4]: https://osf.io/x7mu2/ [5]: https://osf.io/mabp8/ [6]: https://osf.io/yhu75/