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# Getting Started ---- Welcome to the landing page for supplemental materials and documents associated with the manuscript entitled _DNA Methylation Associated with Postpartum Depressive Symptoms Overlaps Findings from a Genome-wide Association Meta-Analysis of Depression_. <br> **Additional File 1 – Summary-level data results for individual probes** (csv) dmp_summary_statistics_preg_ppd.csv This file contains the position (chromosome = chr, start/end = position), probe name (cg), coefficient (coef), observed t value (tval), observed p value (obs_p), empirical p value based on 20,000 permutations (emp_p), false discovery rate for empirical p values (p.adj.fdr), q value for the empirical p value (qval), and the presence of a transcription factor binding site (as annotated by the BioConductor package IlluminaHumanMethylationEPICanno.ilm10b2.hg19) for every probe that was included in the final analysis. Hansen KD (2016). IlluminaHumanMethylationEPICanno.ilm10b2.hg19: Annotation for Illumina's EPIC methylation arrays. R package version 0.6.0, https://bitbucket.com/kasperdanielhansen/Illumina_EPIC. **Additional File 2 – DMP-only and DMR-only gene enrichment analysis** (pdf) PPD_GO_supplemental_table.pdf This file contains gene ontology enrichment results in tabular format for the combined set of differentially methylated regions and probes (DMR, DMP) results, enrichment analysis of DMRs only, and enrichment analysis of DMPs only. **Additional File 3 – Enrichment testing of Psychiatric Genomic Consortium (PGC) results** (csv) dmr_genelist_unique_ppd.csv List of the 92 genes overlapped by significant differentially methylated regions (DMRs). **Additional File 4 – Enrichment testing of Psychiatric Genomic Consortium (PGC) supplemental methods** (docx) pgc_enrichment_supplement.docx This file contains additional details about how the 95% confidence intervals were calculated for the PGC enrichment analysis. **Additional File 5 – Supplement to Figure 2 (docx) supplement_to_fig2_ppd.docx** This file contains two additional versions of the differentially methylated region (DMR) highlighted in Figure 2. One figure shows the ComBat-adjusted methyl values for each participant colored by self-identified Census-based race category. The points have been jittered left/right to ease visualization by reducing over-plotting. No vertical adjustment was made. The second figure shows the mean methyl values for each probe contained in the DMR by self-identified Census-based race category. <br> ## About Data Sharing Due to the nature of IRB and participant consent agreements, not all of the data from the Pregnancy, Race, Environment, Genes (PREG) study can be shared. Anyone interested in data access or collaboration should contact Dr. Timothy P. York (timothy.york@vcuhealth.org) for more information.
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