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The aim of the MOBILIZE project is to empower patients with multimorbidity to take a more active role in their health care through a personalized exercise therapy and education program so that they may reduce symptoms of the individual conditions, increase quality of life and physical function and prevent development of other chronic conditions. Strong interdisciplinary collaboration involving many different scientific methodologies and a high degree of patient involvement throughout the entire research process are at the heart of the project to ensure relevance to the patients and the health care system and to make sure that the project is implementable in clinical practice afterwards. The MOBILIZE project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 801790).