Dose-response relationship between exercise and cognition in older adults with and without cognitive impairment: a systematic review and meta-analysis

Contributors:
  1. Tibor Hortobagyi
  2. Eddy van der Zee
  3. Marieke van Heuvelen

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Description: There is insufficient knowledge regarding the dose-response relationship between exercise and cognition in healthy older adults and older adults with cognitive impairments. We will conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to examine the relationship between exercise dose-parameters (program duration, session duration, frequency, intensity) and cognitive function (global cognition, executive function, memory) in older adults with (MCI, VCI, dementia) and without cognitive impairments. We will include single-modality exercise (aerobic, anaerobic, multimodal, psychomotor) intervention studies with quantified training frequency, session duration and program duration and intensity specified objectively or descriptively. We define total exercise duration in minutes as the product of program duration, session duration, and frequency. Cognitive test-specific Hedges' d effect sizes are collected for every study. We will use multilevel mixed-effects models to investigate dose-related predictors of exercise effects. We have included RCT's that were published on or before November 29th, 2017. A total of 36 studies (24 healthy older adults, 12 older adults with cognitive impairments) are included in the analyses. We are currently writing the results and drafting the manuscript.

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