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Category: Project

Description: An integrated proposal for an inhalable, X-ray–triggered hydrogel “containment mesh” to improve local control of lung tumors. The system uses pH-responsive nanoparticles to bias retention in the tumor microenvironment (Gate A) and clinical X-ray exposure to initiate in-situ polymerization into a thin, conformal hydrogel around tumor margins (Gate B). The mesh can optionally carry drugs, radiosensitizers, and imaging dopants (e.g., CT-visible or persistent-luminescent tracers) and includes a reversal (“undo”) pathway via degradable crosslinks (Gate C) for airway safety. The upload includes a full concept write-up, design spec (materials, dose windows, aerosol parameters), a novelty/FOA check across papers, patents, and trials, plus a staged plan for benchtop → ex-vivo → orthotopic studies and a preliminary regulatory route (combination product, SBRT-adjunct). The goal is to translate independently validated building blocks (inhaled airway-tolerant gels, X-ray–programmable gelation, inhalable trigger-logic platforms) into a first-in-class tumor-containment scaffold that complements radiotherapy by limiting dissemination while enabling precise, on-table QA and safety off-ramps.