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Profiling NMDA receptor in schizophrenia and predicting clinical trajectories from rsEEG using dynamic causal modelling
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Description: NMDA receptor; schizophrenia; dynamic causal models; generative embedding; resting-state EEG; ketamine;
Abstract
The richness of chemical signalling in the brain supports the flexible neural dynamics required for adaptive behaviour. The NMDA receptor, one of the most ubiquitous receptors in the brain, controls synaptic plasticity and mediates learning and memory formation. Its dysfunction is theorised to be one of the mechanisms of schizophrenia. Profiling the changes and dysfunctions of ion channel…
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