UNILATERAL DEEP BRAIN STIMULATION OF SUBTHALAMIC NUCLEUS DOES NOT AFFECT INHIBITORY CONTROL

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Description: Does inhibitory control of arm movements rely just upon the right subthalamic nucleus? Here we tested this hypothesis by comparing The behavioural performance in the stop signal task of Parkinson’s patients who received unilateral deep-brain stimulation (DBS) of the STN either of the left (n=10) or of the right (n=10) hemisphere and in 22 age-matched healthy participants. We found that inhibitory control is impaired in Parkinson’s patients with respect to healthy participants. However, neither reactive nor proactive inhibition is improved when either the right or the left DBS is active.

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The present project aims to test the hotly debated hypothesis that, in humans, the inhibitory control of arm movements relies upon a right-lateralized network, in particular of the right subthalamic nucleus (STN) To assess the role of this subcortical brain region, we took advantage of a relatively rare model, i.e. advanced Parkinson’s patients who received unilateral deep-brain stimulation (DBS)...

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