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Reproducibility Project: Cancer Biology  /

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Description: Selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010 and 2012 are being replicated.

License: CC-By Attribution 4.0 International

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Study 1: Replication of Poliseno et al., 2010 (Nature)

Pandya, Kerwin, Cowley & 6 more
Replication of "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Includes information to prepare the replication ...

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Study 2: Replication of Sharma et al., 2010 (Cell)

Donham, Haven, McDonald & 6 more
Replication of "A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations". Includes information to prepare the replication ex...

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Study 3: Replication of Gupta et al. 2010 (Nature)

Replication of "Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis". Includes information to prepare the replication e...

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Study 4: Replication of Figueroa et al. 2010 (Cancer Cell)

Replication of "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiati...

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Study 5: Replication of Ricci-Vitiani et al., 2010 (Nature)

Courville, Sampey, Iorns & 4 more
Replication of "Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells”. Includes information to prepare the replicati...

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Study 6: Replication of Kan et al., 2010 (Nature)

Chu, Kwok, Pike & 8 more
Replication of "Diverse somatic mutation patterns and pathway alterations in human cancers”. Includes information to prepare the replication experimen...

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Study 7: Replication of Heidorn et al., 2010 (Cell)

Replication of "Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF”. Includes information to prepare the replication...

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Study 8: Replication of Hatzivassiliou et al., 2010 (Nature)

Pelech, Gallagher, Sutter & 8 more
Replication of "RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth”. Includes information to prepare the replication e...

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Study 9: Replication of Vermeulen et al., 2010 (Nature Cell Biology)

Essex, Pineda, Acharya & 7 more
Replication of "Wnt activity defines colon cancer stem cells and is regulated by the microenvironment”. Includes information to prepare the replicatio...

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Study 10: Replication of Carro et al. 2010 (Nature)

Fiering, Ang, Polyzos & 6 more
Replication of "The transcriptional network for mesenchymal transformation of brain tumours”. Includes information to prepare the replication experime...

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Study 11: Replication of Nazarian et al. 2010 (Nature)

Replication of "Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation”. Includes information to prepare the replication...

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Study 12: Replication of Johannessen et al., 2010 (Nature)

Chu, Kwok, Pike & 8 more
Replication of "COT drives resistance to RAF inhibition through MAP kinase pathway reactivation”. Includes information to prepare the replication expe...

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Study 14: Replication of Poulikakos et al. 2010 (Nature)

Hou, Jones, Unnikrishnan & 6 more
Replication of "RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF”. Includes information to prepare the replicat...

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Study 15: Replication of Sugahara et al., 2010 (Science)

Mantis, Kandela, Aird & 5 more
Replication of "Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs”. Includes information to prepare the replicatio...

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Study 16: Replication of Ward et al., 2010 (Cancer Cell)

Showalter, Hatakeyama, Cajka & 7 more
Replication of "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-...

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Study 17: Replication of Ko et al. 2010 (Nature)

Replication of "Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2”. Includes information to prepare the replication exper...

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Study 18: Replication of Zuber et al. 2011 (Nature)

Replication of "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia”. Includes information to prepare the replication exper...

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Study 19: Replication of Delmore et al., 2011 (Cell)

Aird, Kandela, Mantis & 5 more
Replication of "BET bromodomain inhibition as a therapeutic strategy to target c-Myc”. Includes information to prepare the replication experiments. In...

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Study 20: Replication of Goetz et al., 2011 (Cell)

Replication of "Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis”. Includes information to ...

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Study 21: Replication of Sirota et al., 2011 (Science Translational Medicine)

Kandela, Aird, Iorns & 3 more
Replication of "Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data”. Includes information to prep...

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Study 22: Replication of Raj et al. 2011 (Nature)

Replication of "Selective killing of cancer cells by a small molecule targeting the stress response to ROS”. Includes information to prepare the repli...

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Study 23: Replication of Possemato et al. 2011 (Nature)

Shakya, Wang, Berry & 9 more
Replication of "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer”. Includes information to prepare the repli...

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Study 24: Replication of Tay et al., 2011 (Cell)

Wang, Radomska, Phelps & 5 more
Replication of "Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.”. Includes information to prepare the replic...

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Study 25: Replication of Xu et al., 2011 (Cancer Cell)

Replication of "Oncometabolite 2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases”. Includes information to prepa...

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Study 26: Replication of De Nicola et al. 2011 (Nature)

Evans, Li, Boedeker & 8 more
Replication of "Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis”. Includes information to prepare the replication ex...

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Study 27: Replication of Zhu et al. 2011 (Nature)

Aza-Blanc, Huang, Boyd & 7 more
Replication of "BRCA1 tumour suppression occurs via heterochromatin-mediated silencing”. Includes information to prepare the replication experiments.

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Study 28: Replication of Liu et al., 2011 (Nature Medicine)

yanxuefei, Tang, Chen & 7 more
Replication of "The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44”. Includes information to prepare ...

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Study 29: Replication of Dawson et al., 2011 (Nature)

Replication of "Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia”. Includes information to prepare the re...

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Study 30: Replication of Qian et al. 2011 (Nature)

Replication of "CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis”. Includes information to prepare the replication experime...

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Study 31: Replication of Sumazin et al. 2011 (Cell)

Wang, Ding, de Morrée & 7 more
Replication of "An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma”. Includes inf...

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Study 32: Replication of Chaffer et al. 2011 (PNAS)

Replication of "Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state”. Includes information to prepare the replication e...

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Study 33: Replication of Opitz et al. 2011 (Nature)

Replication of "An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor”. Includes information to prepare the replication experim...

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Study 34: Replication of Kang et al., 2011 (Nature)

Araiza, Bower, Campos & 12 more
Replication of "Senescence surveillance of pre-malignant hepatocytes limits liver cancer development”. Includes information to prepare the replication...

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Study 35: Replication of Chen et al. 2012 (Nature)

Replication of "A restricted cell population propagates glioblastoma growth after chemotherapy”. Includes information to prepare the replication exper...

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Study 36: Replication of Driessens et al. 2012 (Nature)

Replication of "Defining the mode of tumour growth by clonal analysis”. Includes information to prepare the replication experiments.

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Study 37: Replication of Garnett et al., 2012 (Nature)

Heuvel, Maddox, Maalouf & 5 more
Replication of "Systematic identification of genomic markers of drug sensitivity in cancer cells”. Includes information to prepare the replication exp...

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Study 38: Replication of Schepers et al. 2012 (Science)

Replication of "Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas”. Includes information to prepare the replication experi...

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Study 39: Replication of Willingham et al., 2012 (PNAS)

Replication of "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors”. Includes information to ...

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Study 40: Replication of Straussman et al., 2012 (Nature)

Replication of "Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion”. Includes information to prepare the repli...

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Study 41: Replication of Arthur et al., 2012 (Science)

Eaton, Pirani, Snitkin & 5 more
Replication of "Intestinal inflammation targets cancer-inducing activity of the microbiota”. Includes information to prepare the replication experimen...

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Study 42: Replication of Peinado et al., 2012 (Nature Medicine)

Kim, Afshari, Sengupta & 8 more
Replication of "Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET”. Includes information to prepare...

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Study 43: Replication of Malanchi et al., 2012 (Nature)

Incardona, Doroudchi, Ismail & 9 more
Replication of "Interactions between cancer stem cells and their niche govern metastatic colonization”. Includes information to prepare the replicatio...

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Study 44: Replication of Berger et al., 2012 (Nature)

Horrigan, Courville, Sampey & 7 more
Replication of "Melanoma genome sequencing reveals frequent PREX2 mutations”. Includes information to prepare the replication experiments. Includes da...

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Study 45: Replication of Prahallad et al. 2012 (Nature)

Replication of "Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR”. Includes information to prepare the r...

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Study 46: Replication of Wilson et al., 2012 (Nature)

Greenfield, Chou, Bencsics & 7 more
Replication of "Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors”. Includes information to prepare the replica...

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Study 47: Replication of Lu et al., 2012. (Nature)

Replication of "IDH mutation impairs histone demethylation and results in a block to cell differentiation". Includes information to prepare the replic...

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Study 48: Replication of Lin et al., 2012 (Cell)

Replication of "Transcriptional amplification in tumor cells with elevated c-Myc”. Includes information to prepare the replication experiments. Includ...

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Study 49: Replication of Lee et al. 2012 (Cell)

Replication of "Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks”. Includes information to prep...

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Study 50: Replication of Castellarin et al., 2012 (Genome Research)

Repass, Iorns, Denis & 3 more
Replication of "Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma”. Includes information to prepare the replication experim...

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Study 51: Replication of Crasta et. al. 2012 (Nature)

Replication of "DNA breaks and chromosome pulverization from errors in mitosis”. Includes information to prepare the replication experiments.

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Study 52: Replication of Png et al. 2011 (Nature)

Replication of "A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells”. Includes information to prepare the replicat...

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Study 53: Replication of Metallo et al. 2012 (Nature)

Richardson, Scott, Zagnitko & 8 more
Replication of "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia”. Includes information to prepare the replication experiment...

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Study 54: Replication of Morin et al. 2010 (Nature Genetics)

Replication of "Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin”. Includes informa...

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