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Reproducibility Project: Cancer Biology /
Replication Studies
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Description: Selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010 and 2012 are being replicated.
Additional information about the Replication Studies published in eLife. can be found here.
The Reproducibility Project: Cancer Biology is a collaboration between Science Exchange and the Center for Open Science, and is independently replicating a subset of experimental results from a substantial number of high-profile cancer biology studies published between 2010-2012 using the Science Exchan…
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Study 1: Replication of Poliseno et al., 2010 (Nature)
Replication of "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Includes information to prepare the replication ...
Study 2: Replication of Sharma et al., 2010 (Cell)
Replication of "A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations". Includes information to prepare the replication ex...
Study 3: Replication of Gupta et al. 2010 (Nature)
Replication of "Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis". Includes information to prepare the replication e...
Study 4: Replication of Figueroa et al. 2010 (Cancer Cell)
Replication of "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiati...
Study 5: Replication of Ricci-Vitiani et al., 2010 (Nature)
Replication of "Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells”. Includes information to prepare the replicati...
Study 6: Replication of Kan et al., 2010 (Nature)
Replication of "Diverse somatic mutation patterns and pathway alterations in human cancers”. Includes information to prepare the replication experimen...
Study 7: Replication of Heidorn et al., 2010 (Cell)
Replication of "Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF”. Includes information to prepare the replication...
Study 8: Replication of Hatzivassiliou et al., 2010 (Nature)
Replication of "RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth”. Includes information to prepare the replication e...
Study 9: Replication of Vermeulen et al., 2010 (Nature Cell Biology)
Replication of "Wnt activity defines colon cancer stem cells and is regulated by the microenvironment”. Includes information to prepare the replicatio...
Study 10: Replication of Carro et al. 2010 (Nature)
Replication of "The transcriptional network for mesenchymal transformation of brain tumours”. Includes information to prepare the replication experime...
Study 11: Replication of Nazarian et al. 2010 (Nature)
Replication of "Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation”. Includes information to prepare the replication...
Study 12: Replication of Johannessen et al., 2010 (Nature)
Replication of "COT drives resistance to RAF inhibition through MAP kinase pathway reactivation”. Includes information to prepare the replication expe...
Study 14: Replication of Poulikakos et al. 2010 (Nature)
Replication of "RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF”. Includes information to prepare the replicat...
Study 15: Replication of Sugahara et al., 2010 (Science)
Replication of "Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs”. Includes information to prepare the replicatio...
Study 16: Replication of Ward et al., 2010 (Cancer Cell)
Replication of "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-...
Study 17: Replication of Ko et al. 2010 (Nature)
Replication of "Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2”. Includes information to prepare the replication exper...
Study 18: Replication of Zuber et al. 2011 (Nature)
Replication of "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia”. Includes information to prepare the replication exper...
Study 19: Replication of Delmore et al., 2011 (Cell)
Replication of "BET bromodomain inhibition as a therapeutic strategy to target c-Myc”. Includes information to prepare the replication experiments. In...
Study 20: Replication of Goetz et al., 2011 (Cell)
Replication of "Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis”. Includes information to ...
Study 21: Replication of Sirota et al., 2011 (Science Translational Medicine)
Replication of "Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data”. Includes information to prep...
Study 22: Replication of Raj et al. 2011 (Nature)
Replication of "Selective killing of cancer cells by a small molecule targeting the stress response to ROS”. Includes information to prepare the repli...
Study 23: Replication of Possemato et al. 2011 (Nature)
Replication of "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer”. Includes information to prepare the repli...
Study 24: Replication of Tay et al., 2011 (Cell)
Replication of "Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.”. Includes information to prepare the replic...
Study 25: Replication of Xu et al., 2011 (Cancer Cell)
Replication of "Oncometabolite 2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases”. Includes information to prepa...
Study 26: Replication of De Nicola et al. 2011 (Nature)
Replication of "Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis”. Includes information to prepare the replication ex...
Study 27: Replication of Zhu et al. 2011 (Nature)
Replication of "BRCA1 tumour suppression occurs via heterochromatin-mediated silencing”. Includes information to prepare the replication experiments.
Study 28: Replication of Liu et al., 2011 (Nature Medicine)
Replication of "The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44”. Includes information to prepare ...
Study 29: Replication of Dawson et al., 2011 (Nature)
Replication of "Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia”. Includes information to prepare the re...
Study 30: Replication of Qian et al. 2011 (Nature)
Replication of "CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis”. Includes information to prepare the replication experime...
Study 31: Replication of Sumazin et al. 2011 (Cell)
Replication of "An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma”. Includes inf...
Study 32: Replication of Chaffer et al. 2011 (PNAS)
Replication of "Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state”. Includes information to prepare the replication e...
Study 33: Replication of Opitz et al. 2011 (Nature)
Replication of "An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor”. Includes information to prepare the replication experim...
Study 34: Replication of Kang et al., 2011 (Nature)
Replication of "Senescence surveillance of pre-malignant hepatocytes limits liver cancer development”. Includes information to prepare the replication...
Study 35: Replication of Chen et al. 2012 (Nature)
Replication of "A restricted cell population propagates glioblastoma growth after chemotherapy”. Includes information to prepare the replication exper...
Study 36: Replication of Driessens et al. 2012 (Nature)
Replication of "Defining the mode of tumour growth by clonal analysis”. Includes information to prepare the replication experiments.
Study 37: Replication of Garnett et al., 2012 (Nature)
Replication of "Systematic identification of genomic markers of drug sensitivity in cancer cells”. Includes information to prepare the replication exp...
Study 38: Replication of Schepers et al. 2012 (Science)
Replication of "Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas”. Includes information to prepare the replication experi...
Study 39: Replication of Willingham et al., 2012 (PNAS)
Replication of "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors”. Includes information to ...
Study 40: Replication of Straussman et al., 2012 (Nature)
Replication of "Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion”. Includes information to prepare the repli...
Study 41: Replication of Arthur et al., 2012 (Science)
Replication of "Intestinal inflammation targets cancer-inducing activity of the microbiota”. Includes information to prepare the replication experimen...
Study 42: Replication of Peinado et al., 2012 (Nature Medicine)
Replication of "Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET”. Includes information to prepare...
Study 43: Replication of Malanchi et al., 2012 (Nature)
Replication of "Interactions between cancer stem cells and their niche govern metastatic colonization”. Includes information to prepare the replicatio...
Study 44: Replication of Berger et al., 2012 (Nature)
Replication of "Melanoma genome sequencing reveals frequent PREX2 mutations”. Includes information to prepare the replication experiments. Includes da...
Study 45: Replication of Prahallad et al. 2012 (Nature)
Replication of "Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR”. Includes information to prepare the r...
Study 46: Replication of Wilson et al., 2012 (Nature)
Replication of "Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors”. Includes information to prepare the replica...
Study 47: Replication of Lu et al., 2012. (Nature)
Replication of "IDH mutation impairs histone demethylation and results in a block to cell differentiation". Includes information to prepare the replic...
Study 48: Replication of Lin et al., 2012 (Cell)
Replication of "Transcriptional amplification in tumor cells with elevated c-Myc”. Includes information to prepare the replication experiments. Includ...
Study 49: Replication of Lee et al. 2012 (Cell)
Replication of "Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks”. Includes information to prep...
Study 50: Replication of Castellarin et al., 2012 (Genome Research)
Replication of "Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma”. Includes information to prepare the replication experim...
Study 51: Replication of Crasta et. al. 2012 (Nature)
Replication of "DNA breaks and chromosome pulverization from errors in mitosis”. Includes information to prepare the replication experiments.
Study 52: Replication of Png et al. 2011 (Nature)
Replication of "A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells”. Includes information to prepare the replicat...
Study 53: Replication of Metallo et al. 2012 (Nature)
Replication of "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia”. Includes information to prepare the replication experiment...
Study 54: Replication of Morin et al. 2010 (Nature Genetics)
Replication of "Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin”. Includes informa...
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