High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFbeta pathway activation

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These data are linked to the following publication doi: 10.1101/753830 Madsen, R. R. et al. (2019) High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation. bioRxiv (preprint).

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  • High_depth_iPSCs_H1047R_RNAseq

    Files and scripts of relevance to the analysis of the high-depth RNA sequencing data, obtained from human induced pluripotent stem cells with the foll...

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  • M98_iPSCs_E418K_RNAseq

    Files and scripts of relevance to the analysis of the RNA sequencing data, obtained from human induced pluripotent stem cells with the following PIK3C...

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  • MEF_H1047R_RNAseq

    Madsen, Semple, Vanhaesebroeck & 1 more
    Files and scripts of relevance to the analysis of the RNA sequencing data, obtained from mouse embryonic fibroblasts with the following PIK3CA genotyp...

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  • GF_replete_iPSCs_H1047R_RPPA_study

    Files and scripts of relevance to the analysis of the reverse phase protein array (RPPA) data, obtained from human induced pluripotent stem cells with...

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  • BYL719_iPSCs_H1047R_RPPA_study

    Files and scripts of relevance to the analysis of the reverse phase protein array (RPPA) data, obtained from human induced pluripotent stem cells with...

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  • Total_proteomics

    This component contains files and scripts of relevance to the analyses of the total proteomics dataset obtained from human induced pluripotent stem ce...

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  • NODAL_experiment

    Files and scripts of relevance to the analysis of RT-qPCR data obtained from an experiment with human induced pluripotent stem cells with the followin...

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  • TCGA_BRCA_PIK3CA_NODAL_analysis

    Script and files associated with the analysis of TCGA breast invasive carcinoma (BRCA) samples positive for PIK3CA-H1047R.

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  • WGCNA_iPSC_RNAseq_analysis

    Weighted Gene Correlation Network Analysis (WGCNA) based on the high-depth RNA sequencing performed on human induced pluripotent stem cells with the f...

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