In response to concerns of ego-depletion replicability, we have developed a within-subject, repeated-measures paradigm to complement the traditional between-subject design. The new paradigm consists of a series of 12 to 22 blocks of alternating depleting and rejuvenating manipulations, with each block followed by a measurement of self-reported energy and the measurement of some aspect of control. Across four studies, we examine three dependent variables that are influenced by depletion: the cognitive estimation task, the flanker task, and solvable sets of anagrams. Participants consistently report having less energy on depleting trials compared to rejuvenating trials, confirming the effectiveness of brief ego-depletion manipulations, at least in terms of self-report. We replicate previous findings showing that participants perform poorer on the cognitive estimation task and make more errors on incongruent trials in the flanker task when depleted. Furthermore, we find indirect effects of depletion on the number of solvable anagrams completed in a restricted time period, as well as evidence that the mechanism for this decreased performance is not reduced perseverance, but instead a failure to regulate time use efficiently. We conclude that ego depletion can be studied using statistically powerful within-subject design.